Nitriles, penicillamine, and substituted prolines
نویسندگان
چکیده
منابع مشابه
Conformational preferences of substituted prolines in the collagen triple helix.
Researchers have recently questioned the role hydroxylated prolines play in stabilizing the collagen triple helix. To address these issues, we have developed new molecular mechanics parameters for the simulation of peptides containing 4(R)-fluoroproline (Flp), 4(R)-hydroxyproline (Hyp), and 4(R)-aminoproline (Amp). Simulations of peptides based on these parameters can be used to determine the c...
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A range of 4-substituted prolines can be rapidly synthesized from a protected glycine Schiff base in only four steps and in 27-55% overall yield. Phase transfer catalysis allows direct access to both enantiomeric series, and the relative stereochemistry at the 4-position is readily controlled (>10:1 dr) through the choice of hydrogenation conditions.
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4 B r o m o x a n t h o t o x i n r e a c t s w i t h c y a n o a c e t a m i d e t o f o r m 4 b r o m o 5 , 6 d i h y d r o x a n t h o t o x i n , w h i c h o n h y d r o l y s i s w i t h c o l d h y d r o c h l o r i c a c i d l e a d s t o t h e f o r m a t i o n o f c y a n o a c e t i c a c i d d e r i v a t i v e , b u t h y d r o l y s i s b y b o i l e d h y d r o c h l o r i c a c i...
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Preparations of N-[3-(hetero)aryl-aminocarbonyl]propanoyl-L-proline derivatives 12, 13, 22 and 23 are described. A novel approach consists of fusing (80-100 °C) N-(hetero)aryl-succinimides (7, 8, 20, 21) with unprotected L-proline and imidazole in the presence of dimethylformamide. In vitro tests for angiotensin converting enzyme (ACE) inhibition showed that all N-(arylaminocarbonyl)-propanoyl-...
متن کاملSolid-Phase Synthesis of Amine/Carboxyl Substituted Prolines and Proline Homologues: Scope and Limitations.
A solid-phase procedure is used to synthesize racemic peptidomimetics based on the fundamental peptide unit. The peptidomimetics are constructed around proline or proline homologues variably substituted at the amine and carbonyl sites. The procedure expands the diversity of substituted peptidomimetic molecules available to the Distributed Drug Discovery (D3) project. Using a BAL-based solid-pha...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 1977
ISSN: 0003-4967
DOI: 10.1136/ard.36.suppl_2.63